blow one's brains out
blow one's brains out {v. phr.}
1. To shoot yourself in the head.
Mr. Jones lost all his wealth, so he blew his brains out.
2. {slang}
To work very hard; overwork yourself.
The boys blew their brains out to get the stage ready for the play.
Mary is not one to blow her brains out.
Compare: BREAK ONE'S NECK.
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Source: A Dictionary of American Idioms