down with a disease down with a disease {adj. phr.} Ill or sick. Aunt Liz is down with the flu this week; she has to stay in bed. Categories: add yours {adj. phr.} Source: A Dictionary of American Idioms by A. Makkai, M.T. Boatner, J.E. Gates © 2024 To section: D Subscribe to: American IdiomsIdioms feedEnglish languageHome page and general feed Leave my opinion